Comparative Study of "Atenolon" Form Different Three Brand in Bangladesh

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Pulse lessening accomplished with β-blockers and diuretics is the best recorded intercession to date for counteractive action of cardiovascular dreariness and demise in patients with hypertension. Left ventricular hypertrophy (LVH) is a solid free marker of danger of cardiovascular dismalness and passing. We intended to set up whether specific obstructing of angiotensin II enhances LVH past diminishing circulatory strain and, subsequently, decreases cardiovascular grimness and passing [1]

Hypertension is a standout amongst the most critical modifiable hazard factors for cardiovascular infection. It is a to a great degree normal finding in the network and a hazard .factor for myocardial dead tissue, stroke, congestive heart disappointment, end-organize renal infection, and fringe vascular ailment. [2,3,4,5,6]

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pharmacological treatment of hypertension has been appeared to diminish the danger of cardiovascular malady complexities, including stroke, coronary illness, and renal inadequacy. [7,8,9]

In NHANES (The National Health and Nutrition Examination Survey)

1999 – 2000, 28.7% of individuals had hypertension. An aggregate of 68.9% of individuals with hypertension knew about the analysis, 58.4% got treatment, and just in 31.0% was the BP controlled. [10]

Here are some key focuses about hypertension

  • Ordinary circulatory strain is 120 more than 80 mm of mercury (mmHg), yet hypertension is higher than 130 more than 80 mmHg.
  • Acute reasons for hypertension incorporate pressure, yet it can occur without anyone else, or it can come about because of a basic condition, for example, kidney sickness.
  • Unmanaged hypertension can prompt a heart assault, stroke, and different issues.
  • Lifestyle factors are the most ideal approach to address hypertension. [11]

A standout amongst the most hazardous parts of hypertension is that you may not realize that you have it. Truth be told, about 33% of individuals who have hypertension don't have any acquaintance with it. The best way to know whether your circulatory strain is high is through general checkups. This is particularly critical in the event that you have a nearby relative who has hypertension.

On the off chance that your circulatory strain is to a great degree high, there might be sure side effects to watch out for,including:

  • Severe headache
  • Fatigue or confusion
  • Vision problems
  • Chest pain
  • Difficulty breathing
  • Irregular heartbeat
  • Blood in the urine
  • Pounding in your chest, neck, or ears.

Less Sleep is a Risk Factor for Hypertension. The pervasiveness of hypertension has expanded over the previous decade in spite of upgrades in mindfulness, treatment, and control of the illness [12]

At this same time, the average sleep in the United States has Gradually declined and has been fueled by increased opportunities to engage in activities that compete for the time allotted to sleep. [13]

Abundance weight and even unobtrusive grown-up weight pick up significantly increment chance for hypertension. Weight reduction decreases the hazard for hypertension [14]

Prescriptions for hypertension

In case you're determined to have hypertension, your specialist may prescribe taking at least one medications to monitor it.

These more often than not should be taken once per day.

Regular circulatory strain meds include:

  • ACE inhibitors – such as enalapril, lisinopril, perindopril and ramipril
  • Angiotensin-2 receptor blockers (ARBs) – such as candesartan, irbesartan, losartan, valsartan and olmesartan
  • Calcium channel blockers – such as amlodipine, felodipine and nifedipine or diltiazem and verapamil.
  • Diuretics – such as indapamide and bendroflumethiazide
  • Beta-blockers – such as atenolol and bisoprolol

Atenolol: (atenolol), a synthetic, beta1-selective (cardioselective) adrenoreceptor blocking agent, may be chemically described as benzeneacetamide, 4-[2'-hydroxy-3'- [(1 methylethyl)amino]propoxy]-. The molecular and structural formulas are:


Atenolol (free base) has a molecular weight of 266. It is a relatively polar hydrophilic compound with a water solubility of 26.5 mg/mL at 37C and a log partition coefficient (octanol/water) of 0.23. It is freely soluble in 1N HCl (300 mg/mL at 25C) and less soluble in chloroform (3 mg/mL at 25C).

Mechanism of Action:

Atenolol has a place with a class of medications called beta blockers. A class of medications is a gathering of meds that work comparatively. These medications are regularly used to treat comparative conditions.

Beta receptors are found on cells in the heart. At the point when adrenaline actuates a beta receptor, pulse and heart rate go up. Beta blockers keep adrenaline from influencing beta receptors in your veins and heart. This causes veins to unwind. By unwinding the vessels, beta blockers help to bring down circulatory strain and diminish chest torment. They additionally help to diminish the heart's interest for oxygen.

Beta blockers don't forever change pulse and chest torment. Rather, they help to deal with the indications.

Genuine side effect:

Summon your specialist right in the event that you have genuine symptoms. Call 911 if your side effects feel dangerous or on the off chance that you believe you're having a medicinal crisis. Genuine reactions and their side effects can incorporate the accompanying

Side effects can include:

  • Allergic response.
  • a huge, red rash
  • fever
  • swelling of the hands, feet, and lower legs
  • swelling of your throat or tongue

Alerts for different gatherings

For pregnant ladies: Atenolol is a classification D pregnancy medicate. That implies two things:

Studies demonstrate a danger of unfavorable impacts to the baby when the mother takes the medication.

The advantages of taking atenolol amid pregnancy may exceed the potential dangers in specific cases.

Atenolol use in the second trimester of pregnancy has been related with birth of infants who are littler than ordinary. Likewise, babies of moms who took atenolol at the season of birth might be in danger of hypoglycemia (lower than typical glucose levels) and bradycardia (slower than ordinary pulse).

On the off chance that you take atenolol and are thinking about having a child, or on the off chance that you are pregnant, converse with your specialist immediately. Atenolol isn't the main solution that treats hypertension. Different medications have less antagonistic impacts amid pregnancy and breastfeeding. Your specialist will have the capacity to let you know whether an alternate medication or a measurements change is a possibility for you.

In the event that you end up pregnant while taking this medication, summon your specialist right.

For ladies who are breastfeeding: Atenolol is consumed into bosom drain and could be passed to a kid who is breastfed. Infants who breastfeed from moms who go for broke atenolol are likewise in danger of hypoglycemia and bradycardia.

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