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The Functional System Of Oncogenesis

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In the work of the functional system of oncogenesis, the nervous and endocrine systems do not participate, since they did not participate in the formation of diapausing somatic embryos in sponges and plants that have no nervous and endocrine systems. The functional system of oncogenesis is controlled by the mechanism of intercellular and interstitial interactions.

Tumor regression

Cancer treatment is a painful process that does not always lead to the desired result. But the possibility of painless treatment of this disease is. This is evidenced by the existence of a tumor regression mechanism. Tumor regression is the recovery of an oncological patient without medical intervention. If we could understand how the mechanism of tumor regression works, and artificially start it in cancer patients, we could get rid of surgery, chemotherapy and radiotherapy. The way to decipher the mechanism of tumor regression is to decipher the mechanism of the evolutionary predecessor of this process. The evolutionary precursor of tumor regression is the resorption of a diapause-preparing somatic embryo of sedentary modular species, which is referred to in section 3.

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Changing the method of asexual reproduction (transition from the formation of modules preparing for diapause to the formation of modules developing without stopping) it indicates the functional plasticity of the reproductive system of the individual. Functional plasticity of the reproductive system occurs when the population lives in an environment in which the living conditions are unstable. In the ocean and in large seas due to the presence of large amounts of water, the conditions of existence cannot change dramatically and quickly. Unstable environment in small bodies of water – in bays, estuaries, separated from the sea waters. Since the tumor regression mechanism exists, vertebrates probably originated from sedentary modular invertebrates that lived in water bodies, the conditions of existence in which rapidly and sharply changed.

Oncogenesis – accelerator of evolution

There is a hypothesis that oncogenesis selectively weeds out of populations of insufficiently adapted to the habitat of individuals. In human populations, the natural selection is opposed by the health care system. The resulting slowdown leads to an increase in the number of carriers of harmful mutations, that is, to the accumulation in populations of genetic cargo. This load grows, reducing homeostatic properties of populations. Living systems have the ability to counteract harmful changes in them. Populations also have this property. Human cancer is probably a way to counter the growth of populations in their genetic cargo. To this opinion inclined the ideas contained in the articles Sommer [123] A. V. Liechtenstein [36]. These authors suggest that using cancer eliminated individuals, genetic inferiority which is for populations in danger. Malignant neoplasms, they write, killing defective individuals and accelerating this evolution, act for the benefit of populations. Cancer counteracts the growth of harmful mutations in human populations. He’s an evolution medic.

The mechanism of oncogenesis is likely to be activated in cases where environmental conditions change so quickly that natural selection does not keep up with them. As a result of this lag, the adaptation of populations to the environment is reduced and they are threatened with going into oblivion. Cancer of modern man is probably a compensatory reaction of supra-organizational systems of populations to the activities of doctors fighting for the extension of life carriers of harmful mutations. Improving the health care system will further inhibit the natural selection.

If Sommer and A.V. Lichtenstein are right, the more successful doctors will be in treating non-oncological diseases, the greater will be the genetic burden in the populations and the more people will suffer from cancer. From the views of Sommer and A. V. Liechtenstein, it follows that cancer is the price that humanity is forced to pay for resisting natural selection. Currently, the health care system is improving in developed countries. It should be thought that it will continue to improve in these countries. The mechanism of oncogenesis is likely to be deciphered and cancer will cease to be a threat to man. When this happens, the imbalance of society will increase even more, and to maintain the sustainability of this imbalance, society will have to spend even more energy than now.

Metazoa’s transition from modular to unitary state increased the role of the population’s supra-organizational system in the adaptation of the species to the environment. Individuals have a unitary functional system of aging a mandatory part of ontogenesis, as it was mandatory to have a functional system updates the modular structure of the ancestors of unitary types. The inevitability of the termination of the existence of a unitary individual is also guaranteed by the functional systems of aging and inflammation. The genes of modular organisms in natural conditions in the mass due to various reasons cease to exist. But they have a chance to live forever. The unitary individuals do not have it.

Have sedentary types of unit modules are an infinite number of times to duplicate their genotype. Therefore, they have populations in which the number of genes may be small or represented by only one. The low genetic diversity of populations of sedentary modular species makes the selection of the most adapted Genets and culling of unsuitable ones ineffective. And because of the slow change of Genets in populations of modular species slowed adaptive genetic adjustment in response to changes in their environment adaptation at the population level is difficult.

In unitary species, duplication of genotypes is impossible. The number of genotypes in populations of unitary species is higher than in populations of modular species. As a result of this and the inevitability of the termination of the existence of a unitary individual is more effective than in the populations of sedentary modular species, is being eliminated from the populations unsuitable genotypes and selection of the most adapted. Adaptive genetic rearrangements of unitary species populations are faster than those of modular species. Aging, inflammation and carcinogenesis is a unitary fee for individuals belonging to populations that can quickly in response to environmental changes genetically to adapt and thus to adapt to the changing environment.

Opportunities and prospects of immortalism

According to V. p. Skulachev and co-authors, it is necessary for animal populations to be genetically reconstructed by natural selection in response to changes in the environment. Humanity is adapting not by evolving, but by transforming the environment to suit its needs. Aging in humans-harmful atavism. It is necessary and can be eliminated [70]. Hope to escape from the need to age prevalent here and abroad. Articles on the Internet devoted to immortalism are evidence of this.

By adapting the environment to its needs, man has destroyed many species. If the decline in biodiversity continues, the evolution of the Earth will accelerate dramatically. Happens compensatory avalanche flash of speciation. Some of the newly emerged species will be pathogenic to humans. Before will be found the means of combating them, they will cause non-immune screening of genotypes. This screening is happening in our time. Disease-causing organisms evolve, humanity in response to this by natural selection evolves towards the development of immunity to them. There is a conjugate evolution of human and disease-causing organisms. Unable to evolve populations of ageless people, which intend to create immortalists, will be due to the emergence of new pathogens and the evolution of existing doomed.

By transforming the environment, man has polluted it. We breathe air containing harmful substances, drink water purified from industrial and household waste, eat food containing heavy metals and pesticides. We’re exposed to radiation and electromagnetic fields. This has resulted in the widespread spread of environmentally-related diseases. In populations of ageless people, which the immortalists intend to create, there will be no change of generations. Natural selection in these populations will stop. Non-aging people will face death not from old age, but from environmentally-related diseases. Therefore, it is unlikely that these populations will last long.

By adapting the environment to its needs, humanity has come close to social, economic and global environmental crises. Intensively using the resources of the environment, it exceeded the capabilities of the biosphere. The rampant growth of the world economy has led to the exhaustion of the planet’s resources. The continuation of the economy is still a disaster. The economic collapse of modern civilization is approaching. In the context of the global environmental and socio-economic crisis, the possibility of human adaptation to the environment by changing it will be narrowed and the role of natural selection will increase.

Man, as all life on Earth is evolving. It is subject to mutations, horizontal gene transfer, genetic recombination, gene drift, and gene allele transfer from one population to another. The mutagenic process in humans accelerated because of the action of the mutagens of anthropogenic origin. Resistance to adverse environmental factors caused by civilization, whether abiotic, biotic or social factors, is a genetically determined characteristic. Individuals are ill, whose mechanisms of adaptation to life in the conditions of scientific and technological progress contain defects. Diseases eliminate genotypes that are unable to resist the adverse factors of urban life, and populations, although very slowly, increase their resistance to these factors.


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